First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece.
Clin Exp Pharmacol Physiol. 2018 Aug;45(8):866-869. doi: 10.1111/1440-1681.12928. Epub 2018 Mar 23.
The role of serum uric acid (SUA) in cardiovascular risk prediction remains to be further determined. We assessed the predictive value of SUA for the incidence of coronary artery disease (CAD) in 2287 essential hypertensive patients who were followed up for a mean period of 8 years. The distribution of SUA levels at baseline was split by the median (5.2 mg/dL) and subjects were classified into those with high and low values. Hypertensives who developed CAD (n = 57) compared to those without CAD at follow-up (n = 2230) had at baseline higher SUA. In multivariate Cox regression model, among established confounders, high SUA (hazard ratio = 1.216, P = .016) turned out to be independent predictor of CAD. In essential hypertensive patients SUA independently predicts CAD.
血清尿酸（SUA）在心血管风险预测中的作用仍有待进一步确定。我们评估了 2287 例原发性高血压患者中 SUA 对冠状动脉疾病（CAD）发病率的预测价值，这些患者的平均随访时间为 8 年。根据中位数（5.2mg/dL）将基线时 SUA 水平的分布进行了划分，并将受试者分为高值和低值组。与随访时无 CAD 的患者（n=2230）相比，发生 CAD（n=57）的高血压患者在基线时的 SUA 更高。在多变量 Cox 回归模型中，在既定的混杂因素中，高 SUA（危险比=1.216，P=0.016）是 CAD 的独立预测因子。在原发性高血压患者中，SUA 可独立预测 CAD。
