Fahey J R, Spitalny G L
Infect Immun. 1987 Feb;55(2):490-3. doi: 10.1128/iai.55.2.490-493.1987.
Protective immunity against a lethal malaria challenge infection was passively transferred to naive recipient mice with spleen cells from donor mice bearing a lethal infection with the virulent YM strain of Plasmodium yoelii. Successful transfer of protection was contingent upon the elimination of residual, viable parasites from donor spleen cell suspensions prior to the infusion of cells. Passive transfer experiments failed to detect suppressor cells in the spleens of lethally infected mice because unfractionated spleen cells or T-cell-enriched spleen cells from mice infected with P. yoelii YM did not enhance parasitemias upon infusion into mice infected with cross-reactive nonvirulent P. yoelii 17X. We concluded that a form of protective immunity was generated during the course of virulent infection but that its expression was inconsequential because parasite growth apparently exceeded the capacity of the immune system to clear the infection.
用感染了致命性约氏疟原虫YM株的供体小鼠的脾细胞，将针对致死性疟疾攻击感染的保护性免疫被动转移给未感染的受体小鼠。保护作用的成功转移取决于在输注细胞之前，从供体脾细胞悬液中清除残留的活寄生虫。被动转移实验未能在致死性感染小鼠的脾脏中检测到抑制细胞，因为来自感染约氏疟原虫YM的小鼠的未分级脾细胞或富含T细胞的脾细胞，在注入感染交叉反应性无毒约氏疟原虫17X的小鼠后，并未增强寄生虫血症。我们得出结论，在毒性感染过程中产生了一种保护性免疫形式，但其表达无关紧要，因为寄生虫生长显然超过了免疫系统清除感染的能力。
