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血液透析糖尿病患者的生活质量:一项来自巴勒斯坦的多中心横断面研究。

Quality of life in hemodialysis diabetic patients: a multicenter cross-sectional study from Palestine.

作者信息

Khatib Sohaib T, Hemadneh Mohammad K, Hasan Samer A, Khazneh Emad, Zyoud Sa'ed H

机构信息

Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Nephrology Unit, Internal Medicine Department, An-Najah National University Hospital, An-Najah National University, Nablus, 44839, Palestine.

出版信息

BMC Nephrol. 2018 Feb 28;19(1):49. doi: 10.1186/s12882-018-0849-x.

Abstract

BACKGROUND

Both diabetes and hemodialysis can seriously impair patients' health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in hemodialysis patients with diabetes in Palestine.

METHODS

A cross-sectional study was performed in multiple centers in the period from November 2016 to June 2017. We utilized the Arabic version of EuroQoL 5 Dimensions 5 Levels (EQ-5D-5L) scale and EuroQol-visual analogue scale (EQ-VAS) to measure patients' HRQOL. The study was conducted in six dialysis centers in the North of West Bank, Palestine. Descriptive and comparative statistics were used to describe clinical and socio-demographic features of patients. Multiple linear regression analysis was used to determine the association between clinical and socio-demographic factors and HRQOL score.

RESULTS

One hundred and forty one diabetic patients undergoing hemodialysis were enrolled in our study. Overall, 52.5% of them (74 patients) were males; the patients had a mean age of 60.32 with 52.5% of them aged below 60. The mean ± standard deviation of EQ-5D-5L index and EQ-VAS score was 0.314 ± 0.4 and 50.85±22.43, respectively. The findings of this study suggest that female patients, uneducated patients, unemployed patients, unmarried patients, and patients with more chronic diseases and comorbidities had a significant poor HRQOL scores (p values <0.05). Variables such as marital status and occupational status were significantly (p < 0.05) associated with the QOL score. More specifically, married status and employed patients positively associated with QOL score (β = 0.22; p = 0.016 and β = 0.27; p = 0.013, respectively).

CONCLUSIONS

Among diabetic patients undergoing hemodialysis, married status and being employed were associated with modestly higher scores of QOL. We recommend that healthcare providers give more attention to diabetic dialysis patients who are unemployed and unmarried, as they are at a higher risk of having impaired HRQOL.

摘要

背景

糖尿病和血液透析都会严重损害患者的健康相关生活质量(HRQOL)。本研究旨在获取有助于解决巴勒斯坦糖尿病血液透析患者HRQOL受损相关因素的数据。

方法

2016年11月至2017年6月期间在多个中心进行了一项横断面研究。我们使用阿拉伯语版的欧洲五维健康量表(EQ-5D-5L)和欧洲视觉模拟量表(EQ-VAS)来测量患者的HRQOL。该研究在巴勒斯坦约旦河西岸北部的六个透析中心进行。描述性和比较性统计用于描述患者的临床和社会人口学特征。多元线性回归分析用于确定临床和社会人口学因素与HRQOL评分之间的关联。

结果

141名接受血液透析的糖尿病患者纳入了我们的研究。总体而言,其中52.5%(74名患者)为男性;患者的平均年龄为60.32岁,其中52.5%的患者年龄在60岁以下。EQ-5D-5L指数和EQ-VAS评分的平均值±标准差分别为0.314±0.4和50.85±22.43。本研究结果表明,女性患者、未受过教育的患者、失业患者、未婚患者以及患有更多慢性病和合并症的患者的HRQOL评分明显较差(p值<0.05)。婚姻状况和职业状况等变量与生活质量评分显著相关(p<0.05)。更具体地说,已婚状态和就业患者与生活质量评分呈正相关(β=0.22;p=0.016和β=0.27;p=0.013)。

结论

在接受血液透析的糖尿病患者中,已婚状态和就业与生活质量得分略高有关。我们建议医疗保健提供者更多地关注失业和未婚的糖尿病透析患者,因为他们的HRQOL受损风险更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e194/5831192/3d0f0a14ccd3/12882_2018_849_Fig1_HTML.jpg

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