Elmer E B, Wood W C, Cohen A M, Bamberg M
J Surg Oncol. 1987 Feb;34(2):113-9. doi: 10.1002/jso.2930340210.
Hematoporphyrin derivative (HPD) has the ability to localize with moderate selectivity to tumor tissue, where it can be activated by visible light and produce singlet oxygen-mediated damage to cellular biomolecules. However, HPD is less than ideal as an agent for tumor photoradiation therapy because it produces a period of photosensitivity that can last 30 days or more, and it can be toxic to surrounding tissues such as skin when used in the treatment of subcutaneous metastases. The usefulness of intraarterial injection for refining the selectivity of HPD was investigated in this work. Intraarterial administration of HPD was not found to provide higher tumor levels of HPD, nor was it able to increase significantly the concentration of HPD relative to surrounding tissues, such as skin and muscle. However, fluorescence microscopy findings suggested that some fluorescent HPD component is rapidly accumulated in tumor macrophages following intraarterial injection.
血卟啉衍生物（HPD）具有以中等选择性定位于肿瘤组织的能力，在肿瘤组织中它可被可见光激活，并产生单线态氧介导的对细胞生物分子的损伤。然而，HPD作为肿瘤光辐射治疗的药物并不理想，因为它会产生长达30天或更长时间的光敏期，并且在用于治疗皮下转移瘤时，对皮肤等周围组织可能有毒性。在这项研究中，对动脉内注射以提高HPD的选择性的有效性进行了研究。未发现动脉内给予HPD能使肿瘤组织中的HPD水平更高，相对于皮肤和肌肉等周围组织，也未能显著增加HPD的浓度。然而，荧光显微镜检查结果表明，动脉内注射后，一些荧光HPD成分会迅速在肿瘤巨噬细胞中积累。
