Kondo Manabu, Miyoshi Yuka, Tarumoto Kohji, Hirayama Norie, Sasaki Takahiro, Yamashita Kohji, Yamashita Susumu, Hatao Katsuhiro
Department of Endocrinology and Hematology, Tokuyama Central Hospital, Japan.
Department of Emergency and Critical Care Medicine, Tokuyama Central Hospital, Japan.
Intern Med. 2018 Jul 15;57(14):2041-2043. doi: 10.2169/internalmedicine.0366-17. Epub 2018 Feb 28.
Quinolones are known to induce hypoglycemia, although there is no written report of garenoxacin-induced hypoglycemia. We herein report a case of garenoxacin-induced hypoglycemia in a patient not taking hypoglycemic drugs. An 89-year-old Japanese woman with type 2 diabetes and chronic renal insufficiency requiring hemodialysis was admitted to the emergency department in a comatose state. Her serum glucose measured 1 mg/dL on arrival. The patient had not taken any hypoglycemic drugs recently and had never experienced a hypoglycemic episode. She had received a four-day course of garenoxacin treatment before the emergency admission. Clinicians should therefore recognize the potential risk of hypoglycemia during garenoxacin therapy.
已知喹诺酮类药物可诱发低血糖，尽管目前尚无加替沙星诱发低血糖的书面报告。我们在此报告一例未服用降糖药物的患者发生加替沙星诱发低血糖的病例。一名89岁的日本女性，患有2型糖尿病和需要血液透析的慢性肾功能不全，以昏迷状态被收入急诊科。入院时她的血清葡萄糖测量值为1mg/dL。该患者近期未服用任何降糖药物，也从未经历过低血糖发作。在紧急入院前，她接受了为期四天的加替沙星治疗。因此，临床医生应认识到加替沙星治疗期间发生低血糖的潜在风险。
