Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark.
Acta Neurol Scand. 2018 Jul;138(1):41-46. doi: 10.1111/ane.12914. Epub 2018 Mar 1.
Most studies report that marriage carries a lower risk of stroke than single living. Whether the marriage advantage is applicable with respect to all other marital status categories (unmarried, divorced, widow) remains unclear. We studied marital status and its association with incident stroke.
We included all patients > 40 years of age admitted to hospital for stroke in Denmark during 2003-2012 and compared marital status to the general Danish population (5.5 millions). Relative risks (RR) for stroke were estimated in log-linear Poisson regression models adjusting for age, sex, calendar year, income, and length of education.
A total of 58 847 patients with incident stroke were included. Crude incidence rates of stroke (per 1000 per year) among the four marital status categories were as follows: 1.96 (married), 1.52 (unmarried), 2.36 (divorced), and 5.43 (widowed). Compared to married persons, adjusted risk of stroke was significantly increased for divorced (RR 1.23; CI 1.19-1.27) and unmarried men (RR 1.07; CI 1.03-1.11) but not for widowed men (RR 1.02; CI 0.98-1.06); risk was slightly increased for divorced women (RR 1.10; CI 1.06-1.15) while not for widowed (RR 1.0; CI 0.97-1.03) and unmarried women (RR 0.97; CI 0.97-1.03).
Divorce was associated with higher risk of stroke, especially in men. Living in marriage or as unmarried or widower had only little or no impact on the risk of stroke.
大多数研究报告表明，婚姻患中风的风险低于单身生活。对于所有其他婚姻状况类别（未婚、离婚、丧偶），婚姻优势是否适用尚不清楚。我们研究了婚姻状况及其与中风发病的关系。
我们纳入了 2003 年至 2012 年期间在丹麦因中风住院的所有>40 岁的患者，并将婚姻状况与丹麦普通人群（550 万）进行了比较。使用对数线性泊松回归模型调整年龄、性别、日历年份、收入和受教育程度后，估计中风的相对风险（RR）。
共纳入 58847 例中风发病患者。4 种婚姻状况类别的中风粗发病率（每年每 1000 人）如下：1.96（已婚）、1.52（未婚）、2.36（离婚）和 5.43（丧偶）。与已婚者相比，离婚男性（RR 1.23；CI 1.19-1.27）和未婚男性（RR 1.07；CI 1.03-1.11）中风的调整风险显著增加，但丧偶男性（RR 1.02；CI 0.98-1.06）风险增加不显著；离婚女性（RR 1.10；CI 1.06-1.15）的风险略有增加，而丧偶（RR 1.0；CI 0.97-1.03）和未婚女性（RR 0.97；CI 0.97-1.03）的风险则没有增加。
离婚与中风风险增加相关，尤其是男性。已婚、未婚或丧偶对中风风险的影响很小或没有。
