Hopper A H, Tindall H, Davies J A
Thromb Haemost. 1986 Oct 21;56(2):229-31.
Beta-thromboglobulin (beta TG) is a platelet-specific protein and since its concentration in plasma rises when platelets are activated, it has been used as an indicator of platelet involvement in vascular disease. Since platelets might be involved in the pathogenesis of diabetic microvascular disease we measured urinary beta TG in 20 insulin-dependent diabetics with nephropathy and compared the results with those from 20 normal subjects. Measurement of beta TG in urine was undertaken to avoid errors induced by blood sampling and to gain information over a prolonged period using a single assay. Measurements were made of beta TG, beta 2-microglobulin and total protein in urine collected for 24 h and creatinine and beta 2 microglobulin in plasma. Survival of indium-111-labeled platelets was measured in nine patients. Urinary beta TG was significantly (p less than 0.02) increased in the 20 patients compared with 20 normal volunteers (median value 1.3 vs 0.8 microgram/24 h). There was a strong correlation between urinary beta TG excretion and plasma creatinine concentration (r = 0.8, p less than 0.0001) and plasma beta 2-microglobulin concentration (r = 0.9, p less than 0.0001). Urinary beta TG concentration did not correlate with platelet survival. The results indicate that although urinary beta TG is significantly increased in patients with diabetic nephropathy its concentration in urine correlates with indicators of glomerular filtration rather than with a test of platelet activation.
β-血小板球蛋白（β-TG）是一种血小板特异性蛋白，由于其在血小板被激活时血浆浓度会升高，因此一直被用作血小板参与血管疾病的指标。鉴于血小板可能参与糖尿病微血管疾病的发病机制，我们对20名患有肾病的胰岛素依赖型糖尿病患者的尿β-TG进行了测量，并将结果与20名正常受试者的结果进行了比较。进行尿β-TG测量是为了避免采血引起的误差，并通过单次检测在较长时间内获取信息。对收集的24小时尿液中的β-TG、β2-微球蛋白和总蛋白以及血浆中的肌酐和β2-微球蛋白进行了测量。对9名患者测量了铟-111标记血小板的存活情况。与20名正常志愿者相比，20名患者的尿β-TG显著升高（p<0.02）（中位数分别为1.3 vs 0.8微克/24小时）。尿β-TG排泄与血浆肌酐浓度（r = 0.8，p<0.0001）和血浆β2-微球蛋白浓度（r = 0.9，p<0.0001）之间存在很强的相关性。尿β-TG浓度与血小板存活无关。结果表明，虽然糖尿病肾病患者的尿β-TG显著升高，但其尿中浓度与肾小球滤过指标相关，而非与血小板激活检测相关。
