Odensjö Swenzon G, Chakrabarti M, Sapsed-Byrne S, Whitwam J G
Acta Anaesthesiol Scand. 1986 Oct;30(7):545-8. doi: 10.1111/j.1399-6576.1986.tb02472.x.
The effect of sufentanil on somatosympathetic reflexes and the subsequent reversal of its effects by naloxone have been observed in dogs anaesthetised with alpha-chloralose, paralysed with suxamethonium and artificially ventilated. When the drug was infused at a rate of 2.5 micrograms kg-1 min-1 the late long latency response evoked by Group IV (C) fibres was totally abolished at a mean dose of 6.40 micrograms kg-1 (+/- 0.99 microgram kg-1) (s.e. mean), while retaining a substantial part of the early short latency response evoked by group III (A delta) fibres; subsequently, during the infusion, this response was also totally abolished at a mean dose of 26.2 micrograms kg-1 (+/- 3.2 mg kg-1). The administration of naloxone (2 mg i.v.) completely reversed the effects of sufentanil within 3-5 min in different preparations. Some of the implications of these results are discussed.
在使用α-氯醛糖麻醉、琥珀酰胆碱麻痹并进行人工通气的犬中，观察了舒芬太尼对躯体交感反射的影响以及随后纳洛酮对其作用的逆转情况。当以2.5微克/千克·分钟的速率输注该药物时，IV组（C）纤维诱发的晚期长潜伏期反应在平均剂量6.40微克/千克（±0.99微克/千克）（标准误均值）时完全消失，而保留了III组（Aδ）纤维诱发的早期短潜伏期反应的很大一部分；随后，在输注过程中，该反应在平均剂量26.2微克/千克（±3.2毫克/千克）时也完全消失。在不同制剂中，静脉注射纳洛酮（2毫克）在3 - 5分钟内完全逆转了舒芬太尼的作用。讨论了这些结果的一些意义。
