Synthesis and Evaluation of Bakuchiol Derivatives as Potential Anticancer Agents.

A series of bakuchiol derivatives were synthesized and evaluated for their anti-proliferative and the inhibitory activities on SMMC7721 cell line migration using PX-478 as a positive control. The results showed (,)-4-(7-methoxy-3,7-dimethyl-3-vinyloct-1-en-1-yl)phenol () to have the best activity among the tested compounds, which included PX-478. In addition, compound showed greater inhibitory activity than that of bakuchiol in the transwell migration and invasion assays at every dose. In western blotting tests, compound showed a promising ability to downregulate the expression of HIF-1α and its associated downstream proteins MMP-2 and MMP-9. Moreover, this effect was dose-dependent and could represent a possible mechanism of action for the anticancer activity of compound .