Kubota K, Arai T, Tamura J, Shirakura T, Morita T
Am J Hematol. 1987 Feb;24(2):221-3. doi: 10.1002/ajh.2830240214.
A unique case of pernicious anemia is described. Initially, the percentage of OKT8-positive blood cells was markedly decreased, resulting in an increase in the OKT4/OKT8 ratio. The level of OKT8-positive blood cells was, however, returned to normal after vitamin B12 therapy. The finding may propose a possible role of the imbalance of blood lymphocyte subpopulations on the pathogenesis of pernicious anemia and also a responsibility of vitamin B12 for such a selective reduction in the OKT8-positive blood cells.
描述了一例独特的恶性贫血病例。最初，OKT8阳性血细胞的百分比显著降低，导致OKT4/OKT8比值升高。然而，维生素B12治疗后，OKT8阳性血细胞水平恢复正常。这一发现可能提示血液淋巴细胞亚群失衡在恶性贫血发病机制中可能发挥的作用，以及维生素B12对OKT8阳性血细胞这种选择性减少的影响。
