头孢唑林在异戊二烯弹性体输注装置中的稳定性。

Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices.

机构信息

Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.

出版信息

Clin Ther. 2018 Apr;40(4):664-667. doi: 10.1016/j.clinthera.2018.02.009. Epub 2018 Feb 26.

DOI:10.1016/j.clinthera.2018.02.009

PMID:29496321

Abstract

PURPOSE

The aim was to investigate the stability of cefazolin in elastomeric infusion devices.

METHODS

Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.

FINDINGS

Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.

IMPLICATIONS

These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

摘要

目的

研究头孢唑林在弹性输注装置中的稳定性。

方法

制备含有头孢唑林（3 g/240 mL 和 6 g/240 mL）的弹性装置（Infusor LV），并在 4°C 下储存 72 小时，然后在 35°C 下储存 12 小时，再在 25°C 下储存 12 小时。在规定的时间点抽取一份样品，并分析头孢唑林的浓度。还评估了样品的 pH 值、溶液颜色和颗粒含量的变化。