理解双膦酸盐对骨力学性能影响的最新进展。
Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties.
机构信息
Departments of Anatomy and Cell Biology, Medicine-Nephrology and Orthopaedic Surgery, Indiana University School of Medicine, 635 Barnhill Dr., MS 5035, Indianapolis, IN, 46202, USA.
Department of Biomedical Engineering, Indiana University Purdue University of Indianapolis, Indianapolis, IN, USA.
出版信息
Curr Osteoporos Rep. 2018 Apr;16(2):198-204. doi: 10.1007/s11914-018-0430-3.
Abstract
PURPOSE OF THE REVIEW
Bisphosphonates have well-established effects on suppressing bone resorption and slowing bone loss, yet the effects on bone mechanical properties are less clear. We review recent data from pre-clinical and clinical experiments that assessed mechanical properties of bisphosphonate-treated specimens.
RECENT FINDINGS
Pre-clinical work has utilized new techniques to show reduced fatigue life and transfer of stress from the mineral to collagen. Several notable studies have examined mechanical properties of tissue from patients treated with bisphosphonates with mixed results. Pre-clinical data suggest effects on mechanics may be independent of remodeling suppression. The direct effect of bisphosphonates on bone mechanics remains unclear but recent work has set a solid foundation for the coming years.
摘要
目的综述
双膦酸盐对抑制骨吸收和减缓骨丢失具有明确的作用，但对骨力学性能的影响尚不清楚。我们综述了最近的临床前和临床试验数据，这些数据评估了双膦酸盐处理标本的力学性能。
最近的发现
临床前工作利用新技术表明疲劳寿命缩短，矿物质向胶原蛋白的应力转移。有几项值得注意的研究检查了接受双膦酸盐治疗的患者的组织力学性能，结果喜忧参半。临床前数据表明，力学效应可能与抑制重塑无关。双膦酸盐对骨力学的直接影响尚不清楚，但最近的工作为未来几年奠定了坚实的基础。
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