骨骼研究的临床前模型：常用物种如何模拟（或不模拟）人类骨骼的各个方面。

Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don't) Aspects of Human Bone.

作者信息

Allen Matthew R

机构信息

1 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

2 Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

出版信息

Toxicol Pathol. 2017 Oct;45(7):851-854. doi: 10.1177/0192623317733925. Epub 2017 Sep 25.

DOI:10.1177/0192623317733925

PMID:28946796

Abstract

Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed to understand efficacy and side effects. This brief review highlights 4 aspects of human bone, longitudinal bone growth, intracortical remodeling, collagen/mineral interface, and age-related changes, and discusses how various animal models recapitulate (or don't) these aspects of human skeletal physiology.

摘要

临床前研究在探索肌肉骨骼系统的生物学调节方面发挥着不可或缺的作用。在所有药物研发流程中，都需要进行临床前研究，因为无论是小型还是大型动物模型，对于了解药物疗效和副作用都是必需的。本简要综述重点介绍了人类骨骼的四个方面，即骨骼纵向生长、皮质内重塑、胶原蛋白/矿物质界面以及与年龄相关的变化，并讨论了各种动物模型如何（或未能）模拟人类骨骼生理学的这些方面。