Orlow S, Yasunami R, Boitard C, Bach J F
C R Acad Sci III. 1987;304(3):77-8.
To clarify whether the non-obese diabetes prone (NOD) mouse has an unusual pancreatic sensitivity to damage, mice were administered streptozotocin in high dose (direct beta cell toxic) or multiple low-dose (autoimmune-insulitis generating) regimen. NOD mice were found to be less sensitive to the diabetogenic effects of high-dose streptozotocin than C57BL/6 mice, but were exquisitely responsive to the multiple low dose regimen when compared to C57BL/6 or C3H/HeJ mice. These results suggest that the basic defect in NOD mice resides in the immune system and that the NOD mouse may be a useful model to investigate the relationships between environmental factors and intrinsic genetic predisposition to diabetes.
为了阐明非肥胖糖尿病易感性（NOD）小鼠对胰腺损伤是否具有异常敏感性，给小鼠施用高剂量（直接β细胞毒性）或多次低剂量（产生自身免疫性胰岛炎）方案的链脲佐菌素。发现NOD小鼠对高剂量链脲佐菌素的致糖尿病作用比C57BL / 6小鼠更不敏感，但与C57BL / 6或C3H / HeJ小鼠相比，对多次低剂量方案反应极为敏感。这些结果表明，NOD小鼠的基本缺陷存在于免疫系统中，并且NOD小鼠可能是研究环境因素与糖尿病内在遗传易感性之间关系的有用模型。
