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慢性心力衰竭和心肌病的先进无创成像技术:重点关注心脏磁共振成像和计算机断层扫描。

Advanced Non-invasive Imaging Techniques in Chronic Heart Failure and Cardiomyopathies : Focus on Cardiac Magnetic Resonance Imaging and Computed Tomographic.

机构信息

Graduate School of Medicine and Surgery, Post-graduate Residency School in Cardiology, Department of Clinical and Experimental Medicine - Cardiology Unit, University Hospital Medical School "Gaetano Martino", Messina, Italy.

Graduate School of Medicine and Surgery, Post-graduate Residency School in Cardiology, Department of Radiological Sciences - Radiology Unit, University Hospital Medical School "Gaetano Martino", Messina, Italy.

出版信息

Adv Exp Med Biol. 2018;1067:183-196. doi: 10.1007/5584_2018_183.

Abstract

Cardiomyopathies (Cs) are a heterogeneous group of myocardial diseases with structural and/or functional abnormalities.The aetiology is due to genetic-family substrate in most cases, however, the correct and detailed analysis of morphofunctional abnormalities (severity and distribution of hypertrophy, ventricular dilatation, ventricular dysfunction) and tissue characteristics (myocardial fibrosis, myocardial infiltration) are a crucial element for a definite diagnosis.Among the different diagnostic imaging modalities applied in clinical practice (echocardiography, nuclear medicine), cardiac magnetic resonance (CMR) has emerged as a non-invasive diagnostic tool having high ability to quantify systolic function and tissue abnormalities that represent the substrates of many Cs.The main added value of CMR is the ability to identify cardiomyopathies with respect to ischemic heart disease and, above all, to discriminate the major types of cardiomyopathies based on morpho-functional presentation patterns and the presence and location of myocardial fibrosis.Many CMR elements allow increasing diagnostic accuracy but CMR data should be integrated with an appropriate clinical and instrumental context.Computed Tomographic (CT) scan technology has showed a complementary role in patients having Cs and HF.In this chapter, the diagnostic, pathophysiologic and prognostic value of CMR and CT in heart failure due to the most common cardiomyopathies will be discussed.

摘要

心肌病(Cs)是一组具有结构和/或功能异常的心肌疾病。病因在大多数情况下是遗传-家族基础,但对形态功能异常(肥大、心室扩张、心室功能障碍的严重程度和分布)和组织特征(心肌纤维化、心肌浸润)的正确和详细分析是明确诊断的关键因素。在临床实践中应用的不同诊断成像方式(超声心动图、核医学)中,心脏磁共振(CMR)已成为一种具有高能力定量收缩功能和组织异常的非侵入性诊断工具,这些异常是许多 Cs 的基础。CMR 的主要附加值在于能够识别与缺血性心脏病相关的心肌病,并且最重要的是,能够根据形态功能表现模式以及心肌纤维化的存在和位置来区分主要类型的心肌病。许多 CMR 元素可以提高诊断准确性,但 CMR 数据应与适当的临床和仪器背景相结合。计算机断层扫描(CT)技术在 Cs 和 HF 患者中显示出互补作用。在本章中,将讨论 CMR 和 CT 在最常见的心肌病引起的心力衰竭中的诊断、病理生理和预后价值。

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