Dedman J R
Cell Calcium. 1986 Dec;7(5-6):297-307. doi: 10.1016/0143-4160(86)90034-5.
The discovery of troponin C and calmodulin set the tenor for understanding the intracellular mechanism of action of calcium. These proteins represent cellular receptors and distinct mediators of calcium. More recently, additional calcium-binding proteins have been identified. Immunological and sequence data suggest that these proteins represent a novel family of calcium mediators. The precise pathways in which these proteins are involved are not known. However, function by inference, the mediation of intracellular calcium, provides new avenues in which to better understand the complex cellular role calcium plays in regulating cell function.
肌钙蛋白C和钙调蛋白的发现为理解钙的细胞内作用机制奠定了基调。这些蛋白质代表细胞受体和独特的钙介质。最近，又鉴定出了其他钙结合蛋白。免疫学和序列数据表明，这些蛋白质代表了一个新的钙介质家族。这些蛋白质所涉及的精确途径尚不清楚。然而，通过推断其功能——细胞内钙的介导作用，为更好地理解钙在调节细胞功能中所起的复杂细胞作用提供了新途径。
