新生期用胍乙啶处理的成年大鼠中有助于维持动脉血压的因素。
Factors contributing to the maintenance of arterial blood pressure in adult rats treated neonatally with guanethidine.
作者信息
Bennett T, Gardiner S M
出版信息
Clin Exp Hypertens A. 1986;8(8):1373-94. doi: 10.3109/10641968609044093.
Adult rats treated neonatally with guanethidine had normal arterial blood pressures, but these were more dependent on the renin-angiotensin system than in control animals. Antagonism of V1-receptors (with d(CH2)5DAVP) enhanced the depressor effects of captopril in guanethidine-treated animals, but blood pressure was unaffected by this manoeuvre in control animals. Although there is evidence that sympathetic efferent vasomotor function is abolished following the schedule of neonatal guanethidine treatment used, pentolinium had a hypotensive effect in the presence of d(CH2)5DAVP and captopril, indicating that the adrenal medulla could have been contributing to the maintenance of blood pressure. This is consistent with the finding of marked supersensitivity to exogenous adrenaline in guanethidine-treated rats.
新生期用胍乙啶处理的成年大鼠动脉血压正常，但与对照动物相比，其血压对肾素 - 血管紧张素系统的依赖性更强。V1受体拮抗剂（用d(CH2)5DAVP）增强了卡托普利对胍乙啶处理动物的降压作用，但该操作对对照动物的血压无影响。尽管有证据表明，按照所用的新生期胍乙啶处理方案，交感传出血管运动功能被消除，但潘托铵在d(CH2)5DAVP和卡托普利存在时具有降压作用，这表明肾上腺髓质可能参与了血压的维持。这与胍乙啶处理的大鼠对外源性肾上腺素明显超敏的发现一致。
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