Division of Otology-Neurotology, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Otol Neurotol. 2018 Apr;39(4):e274-e279. doi: 10.1097/MAO.0000000000001744.
To describe the electrocochleography (ECochG) findings in patients with bilateral vestibular paresis and sound- and/or pressure-induced horizontal nystagmus.
Retrospective case series.
Tertiary care center.
Three adult patients with bilateral vestibular paresis and sound- and/or pressure-induced horizontal nystagmus were evaluated from 2012 to 2016.
All patients underwent ECochG, vestibular evoked myogenic potential (VEMP) testing, bithermal caloric testing, rotary chair testing, audiometric testing, and temporal bone computed tomography (CT). For ECochG, the summating potential (SP) to action potential (AP) ratio was determined.
All patients had normal temporal bone CT, reduced caloric responses bilaterally, decreased gain on rotary chair, and abnormal ECochG. For two subjects, the SP/AP was elevated bilaterally. One subject had unilateral SP/AP elevation. Cervical VEMPs were present in all subjects, but at reduced thresholds in two subjects.
SP/AP elevation was found in all three patients with the syndrome of bilateral vestibular paresis and/or sound- or pressure-induced horizontal nystagmus. As the etiology of this syndrome remains unclear, understanding the basis for abnormal ECochG may shed insight into the pathophysiology of this condition.
描述双侧前庭功能减退伴声、压诱导水平性眼震患者的耳蜗电图（ECochG）结果。
回顾性病例系列。
三级医疗中心。
2012 年至 2016 年期间评估了 3 名成人双侧前庭功能减退伴声、压诱导水平性眼震患者。
所有患者均行 ECochG、前庭诱发肌源性电位（VEMP）测试、双侧冷热测、转椅测试、听力学测试和颞骨 CT。ECochG 检测总和电位（SP）与动作电位（AP）比值。
所有患者的颞骨 CT 正常，双侧冷热反应均减弱，转椅增益降低，ECochG 异常。两名患者双侧 SP/AP 升高。一名患者单侧 SP/AP 升高。所有受试者均存在颈性 VEMP，但有两名受试者的阈值降低。
在双侧前庭功能减退和/或声、压诱导水平性眼震的综合征患者中均发现 SP/AP 升高。由于该综合征的病因仍不清楚，了解异常 ECochG 的基础可能有助于深入了解该病症的病理生理学。
