Cancer Pain Program, Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Cancer. 2018 Jun 15;124(12):2491-2497. doi: 10.1002/cncr.31303. Epub 2018 Mar 2.
Cancer pain remains a feared consequence of the disease and its treatment. Although prevalent, cancer pain can usually be managed through the skillful application of pharmacologic and nonpharmacologic interventions. Unfortunately, access to these therapies has been hampered by interventions designed to contain another serious public health problem: the opioid misuse epidemic. This epidemic and the unintended consequences of efforts to control this outbreak are leading to significant barriers to the provision of cancer pain relief. Oncologists and other professionals treating those with cancer pain will require new knowledge and tools to provide safe and effective pain control while preventing additional cases of substance use disorders (SUDs), helping patients in recovery to maintain sobriety, and guiding those not yet in recovery to seek treatment. How do these 2 serious epidemics intersect and affect oncology practice? First, oncology professionals will need to adopt practices to prevent SUDs by assessing risk and providing safe pain care. Second, oncology practices are likely to see an increased number of patients with a current or past SUD, including opioid misuse. Few guidelines exist for the direct management of pain when opioids may be indicated in these individuals. Third, modified prescribing practices along with the education of patients and families are warranted to prevent the exposure of these medications to unintended persons. Finally, advocacy on behalf of those with cancer pain is imperative to avoid losing access to essential therapies, including opioids, for those who might benefit. Cancer 2018;124:2491-7. © 2018 American Cancer Society.
癌症疼痛仍然是这种疾病及其治疗的可怕后果。尽管很普遍,但癌症疼痛通常可以通过熟练应用药物和非药物干预来控制。不幸的是,这些疗法的获得受到了旨在控制另一个严重公共卫生问题——阿片类药物滥用流行的干预措施的阻碍。这种流行以及控制这种疫情的努力的意外后果,导致提供癌症疼痛缓解的重大障碍。治疗癌症疼痛的肿瘤学家和其他专业人员将需要新知识和工具,以提供安全有效的疼痛控制,同时预防额外的物质使用障碍(SUD)病例,帮助康复中的患者保持清醒,并指导尚未康复的患者寻求治疗。这两种严重的流行如何相互交叉并影响肿瘤学实践?首先,肿瘤学专业人员需要通过评估风险和提供安全的疼痛护理来采取预防 SUD 的措施。其次,肿瘤学实践可能会看到更多患有当前或过去 SUD 的患者,包括阿片类药物滥用。对于这些人可能需要使用阿片类药物时,几乎没有直接管理疼痛的指南。第三,需要修改处方实践,并对患者和家属进行教育,以防止这些药物被意外使用。最后,必须代表癌症疼痛患者进行宣传,以避免那些可能受益的患者失去获得包括阿片类药物在内的基本治疗的机会。癌症 2018;124:2491-7。©2018 美国癌症协会。