非均匀制动将 RNA 聚合酶旋转进入暂停状态。
Uneven Braking Spins RNA Polymerase into a Pause.
机构信息
Department of Microbiology and The Center for RNA Biology, The Ohio State University, Columbus, OH, USA.
Department of Biochemistry, University of Turku, Turku, Finland.
出版信息
Mol Cell. 2018 Mar 1;69(5):723-725. doi: 10.1016/j.molcel.2018.02.013.
PMID:29499129
Abstract
In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.
摘要
在本期《分子细胞》中，郭等人（2018 年）和康等人（2018 年）报道了转录复合物暂停的结构，其中异步易位抑制核苷酸的添加，从而允许 RNA 聚合酶在 RNA 发夹和 NusA 稳定下进行全局重排。
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