心血管疾病中的整合应激反应系统。
The integrated stress response system in cardiovascular disease.
机构信息
Institute of Experimental and Clinical Research (IREC), Pneumology, ENT and Dermatology, Université catholique de Louvain (UCL), Brussels, Belgium.
Institute of Experimental and Clinical Research (IREC), Pneumology, ENT and Dermatology, Université catholique de Louvain (UCL), Brussels, Belgium; Cliniques universitaires Mont-Godinne - CHU Namur Godinne, Department of Pneumology, Yvoir, Belgium; UZ Leuven, Department of Pneumology, Leuven, Belgium.
出版信息
Drug Discov Today. 2018 Apr;23(4):920-929. doi: 10.1016/j.drudis.2018.02.008. Epub 2018 Feb 27.
The integrated stress response system represents an ancillary, extremely conserved signalling pathway present in virtually all eukaryotic cells, which plays an important part in the pathophysiology of several disorders such as cancer and neurodegeneration. However, its role in the cardiovascular system remains largely elusive. Hence, this review aims to acknowledge recent findings regarding the action of the eIF2α kinases in the cardiovascular system and their role in the pathophysiology of related disorders.
整合应激反应系统代表了一种辅助的、极其保守的信号通路，存在于几乎所有真核细胞中，在癌症和神经退行性变等多种疾病的病理生理学中发挥着重要作用。然而，它在心血管系统中的作用在很大程度上仍然难以捉摸。因此，本综述旨在承认最近关于 eIF2α 激酶在心血管系统中的作用及其在相关疾病病理生理学中的作用的发现。
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