Bijak A, Pasternac A, McPherson G A, Bevan J A
Eur J Pharmacol. 1986 Dec 16;132(2-3):313-7. doi: 10.1016/0014-2999(86)90623-0.
The potency of the dihydropyridine calcium channel blocker, PN 200-110 was assessed in vitro against contractions induced by potassium (20-55 mM) and histamine (1-300 microM) in rabbit thoracic aorta, coronary, basilar, renal and central ear arteries. PN 200-110 was particularly effective against potassium responses in the coronary and basilar arteries (IC50 30 and 50 pM) and of little effect against histamine responses in the renal artery and thoracic aorta (IC50 greater than 1 microM). These results suggest that PN 200-110 has some preferential actions dependent on both the vascular bed and also the constrictor used.
在体外评估了二氢吡啶类钙通道阻滞剂PN 200 - 110对兔胸主动脉、冠状动脉、基底动脉、肾动脉和中耳动脉中由钾（20 - 55 mM）和组胺（1 - 300 microM）诱导的收缩的作用。PN 200 - 110对冠状动脉和基底动脉中的钾反应特别有效（IC50分别为30和50 pM），而对肾动脉和胸主动脉中的组胺反应几乎没有作用（IC50大于1 microM）。这些结果表明，PN 200 - 110具有一些依赖于血管床和所用收缩剂的优先作用。
