Mellstrom B, Iadarola M J, Costa E
Eur J Pharmacol. 1987 Jan 13;133(2):185-90. doi: 10.1016/0014-2999(87)90149-x.
The effect of the angiotensin converting enzyme inhibitor 2-[N-[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- -azabicyclo(3.3.0)octane-3-carboxylic acid (Hoe 498 diacid) and the aminopeptidase inhibitor bestatin on antinociception induced in rats by intraventricular injections of [Met5]enkephalin-Arg6-Phe7 and [Met5]enkephalin-Arg6-Gly7-Leu8 was investigated. Potentiation and prolongation of the antinociception was observed after pretreatment with bestatin. Further potentiation of the antinociception elicited by the heptapeptide was obtained in rats pretreated with a combination of bestatin and Hoe 498 diacid. In contrast, antinociception elicited by the octapeptide was not potentiated further by pretreatment with the bestatin and Hoe 498 diacid combination.
研究了血管紧张素转换酶抑制剂2-[[(S)-1-羧基-3-苯基丙基]-L-丙氨酰基]-(1S,3S,5S)-2-氮杂双环[3.3.0]辛烷-3-羧酸（Hoe 498二酸）和氨肽酶抑制剂贝司他汀对大鼠脑室内注射[Met5]脑啡肽-Arg6-Phe7和[Met5]脑啡肽-Arg6-Gly7-Leu8诱导的抗伤害感受的影响。用贝司他汀预处理后观察到抗伤害感受增强并延长。在用贝司他汀和Hoe 498二酸联合预处理的大鼠中，七肽引起的抗伤害感受进一步增强。相比之下，八肽引起的抗伤害感受在用贝司他汀和Hoe 498二酸联合预处理后未进一步增强。
