Yaglova N V, Sledneva Yu P, Nazimova S V, Obernikhin S S, Yaglov V V
Research Institute of Human Morphology, Moscow, Russia.
Bull Exp Biol Med. 2018 Mar;164(4):430-433. doi: 10.1007/s10517-018-4005-1. Epub 2018 Mar 3.
Sex differences in the expression of iodide transporter SLC5A5 and thyroid peroxidase in thyroid follicular epithelium and thyroid serum profile were assessed in pubertal rats exposed to endocrine disruptor DDT starting from the first postnatal day. It was found that exposure to DDT reduced expression of SLC5A5 in peripheral regions of thyroid lobes in males and in central regions in females. The most pronounced sex differences were observed in thyroid peroxidase expression that remained sensitive to thyroid stimulating hormone regulation in males and lost sensitivity to pituitary stimulation in females after exposure to disruptor, which determines more pronounced hypothyroidism in females.
从出生后第一天开始，对暴露于内分泌干扰物滴滴涕的青春期大鼠甲状腺滤泡上皮中碘转运体SLC5A5和甲状腺过氧化物酶的表达以及甲状腺血清谱的性别差异进行了评估。结果发现，暴露于滴滴涕会降低雄性大鼠甲状腺叶周边区域和雌性大鼠甲状腺叶中央区域SLC5A5的表达。在甲状腺过氧化物酶表达方面观察到最明显的性别差异，暴露于干扰物后，雄性大鼠的甲状腺过氧化物酶表达仍对促甲状腺激素调节敏感，而雌性大鼠则对垂体刺激失去敏感性，这导致雌性大鼠出现更明显的甲状腺功能减退。
