A miniaturized sorbent phase-based extraction device in the form of syringe filter holder using molecularly imprinted polymer as sorbent and its application to extract benzophenones.

The molecularly imprinted polymer using 2,4-dihydroxybenzophenone as the template (DHBP-MIP) was synthesized via sacrificial support method. The DHBP-MIP was demonstrated to possess good adsorption capacity and selectivity towards benzophenones. Moreover, a miniaturized sorbent phase-based extraction device in the form of syringe filter holder using DHBP-MIP as the sorbent was proposed, and named as μ-SPE-SFH-MIP device. The μ-SPE-SFH-MIP device consisted of a reusable syringe filter holder, flexible amount of sorbent and a sub-microporous membrane, which could be conveniently connected to different driving forces, like syringe pump, solid-phase extraction device and peristaltic pump. It was successfully applied to extract five benzophenones from swimming pool water and human urine samples, combined with high performance liquid chromatograph-UV analysis, with detection limits of 0.12-0.68 μg L and 0.21-1.05 μg L, respectively. The accuracy and precision of the analytes were in the range of 89.27%-113.35% for swimming pool water samples and 90.65%-108.00% for urine samples, with all the relative standard deviation values below 7.89%. The μ-SPE-SFH-MIP device was portable, cost-effective operational convenient and suitable for the small-size samples; moreover, with the MIP as the sorbent, it afforded additional high selectivity and sensitivity.