Université de Reims Champagne-Ardenne, Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, France; Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, Reims, France.
Université de Reims Champagne-Ardenne, Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, France; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, Reims, France.
Adv Drug Deliv Rev. 2018 Apr;129:344-351. doi: 10.1016/j.addr.2018.02.011. Epub 2018 Mar 1.
Wound healing, a complex physiological process, is responsible for tissue repair after exposure to destructive stimuli, without resulting in complete functional regeneration. Injuries can be stromal or epithelial, and most cases of wound repair have been studied in the skin and cornea. Lumican, a small leucine-rich proteoglycan, is expressed in the extracellular matrices of several tissues, such as the cornea, cartilage, and skin. This molecule has been shown to regulate collagen fibrillogenesis, keratinocyte phenotypes, and corneal transparency modulation. Lumican is also involved in the extravasation of inflammatory cells and angiogenesis, which are both critical in stromal wound healing. Lumican is the only member of the small leucine-rich proteoglycan family expressed by the epithelia during wound healing. This review summarizes the importance of lumican in wound healing and potential methods of lumican drug delivery to target wound repair are discussed. The involvement of lumican in corneal wound healing is described based on in vitro and in vivo models, with critical emphasis on its underlying mechanisms of action. Similarly, the expression and role of lumican in the healing of other tissues are presented, with emphasis on skin wound healing. Overall, lumican promotes normal wound repair and broadens new therapeutic perspectives for impaired wound healing.
创伤愈合是一种复杂的生理过程，负责在暴露于破坏性刺激后进行组织修复，而不会导致完全的功能再生。损伤可以是基质性的或上皮性的，大多数伤口修复的情况都在皮肤和角膜中进行了研究。赖氨酰聚糖，一种小型富含亮氨酸的蛋白聚糖，在多种组织的细胞外基质中表达，如角膜、软骨和皮肤。该分子已被证明可调节胶原纤维原纤维的形成、角质形成细胞表型和角膜透明度的调节。赖氨酰聚糖还参与炎症细胞的渗出和血管生成，这两者对于基质性伤口愈合都很关键。赖氨酰聚糖是在伤口愈合过程中上皮细胞中唯一表达的小型富含亮氨酸的蛋白聚糖家族成员。这篇综述总结了赖氨酰聚糖在伤口愈合中的重要性，并讨论了将赖氨酰聚糖作为药物递送来靶向伤口修复的潜在方法。根据体外和体内模型描述了赖氨酰聚糖在角膜伤口愈合中的作用，重点强调了其作用机制。同样，还介绍了赖氨酰聚糖在其他组织愈合中的表达和作用，重点介绍了皮肤伤口愈合。总的来说，赖氨酰聚糖促进正常伤口愈合，并为受损的伤口愈合拓宽了新的治疗视角。
