University of Cambridge, Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, CB2 0QQ, UK.
University of Cambridge, Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, CB2 0QQ, UK.
Semin Cell Dev Biol. 2018 Nov;83:42-50. doi: 10.1016/j.semcdb.2018.02.022. Epub 2018 Mar 9.
Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pathway is well-characterised. However, several cytosolic proteins have now been documented as secreted by unconventional transport pathways. This review focuses on two of these proteins families: annexins and galectins. The extracellular functions of these proteins are well documented, as are associations of their perturbed secretion with several diseases. However, the mechanisms and regulation of their secretion remain poorly characterised, and are discussed in this review. This review is part of a Special Issues of SCDB on 'unconventional protein secretion' edited by Walter Nickel and Catherine Rabouille.
真核细胞具有高度进化的蛋白质分泌系统，该途径的功能障碍与许多疾病有关，包括癌症、感染、代谢疾病和神经紊乱。大多数蛋白质通过传统的内质网（ER）/高尔基体网络进行分泌，因此该途径的特征已经得到很好的描述。然而，现在已经有一些胞质蛋白被证明是通过非传统的运输途径分泌的。本综述重点关注其中两类蛋白质家族：膜联蛋白和半乳糖凝集素。这些蛋白质的细胞外功能已有详细记录，其分泌异常与多种疾病有关。然而，它们分泌的机制和调控仍未得到很好的描述，这在本综述中进行了讨论。这篇综述是由 Walter Nickel 和 Catherine Rabouille 编辑的 SCDB 关于“非传统蛋白质分泌”的特刊的一部分。
