耳硬化症：从遗传学至分子生物学
Otosclerosis: From Genetics to Molecular Biology.
作者信息
Babcock Thomas A, Liu Xue Zhong
机构信息
Department of Otolaryngology, University of Miami Miller School of Medicine, 1120 NorthWest 14th Street, 5th Floor, Miami, FL 33136, USA.
Department of Otolaryngology, University of Miami Miller School of Medicine, 1120 NorthWest 14th Street, 5th Floor, Miami, FL 33136, USA.
出版信息
Otolaryngol Clin North Am. 2018 Apr;51(2):305-318. doi: 10.1016/j.otc.2017.11.002.
Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
在过去的几年里，随着基因和分子研究的发展，耳硬化症的发病机制涉及多种病因。总体而言，目前的证据表明，耳硬化症是一种复杂的疾病，有多种潜在途径导致耳囊内异常骨重塑的发展。这些参与耳硬化症发病机制的途径受到遗传和环境因素的影响。
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