Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Schizophr Res. 2018 Sep;199:297-303. doi: 10.1016/j.schres.2018.02.037. Epub 2018 Mar 2.
Higher levels of circulating oestrogens in women and testosterone in men have been shown to have a protective effect against the clinical manifestations of schizophrenia, mostly with respect to negative symptomatology. Certain studies suggest that they also have a protective effect against the neuropsychological impairment observed in the disease. We investigated whether greater prenatal exposure to estrogens in women and to testosterone in men, reflected by the 2D:4D ratio, was similarly associated with decreased negative symptomatology and improved neuropsychological functioning in patients.
51 schizophrenia patients and 50 healthy participants were administered a neuropsychological battery. The 2D:4D ratio was measured in all participants. Positive, negative, and affective symptoms were assessed in patients. Regression analyses were conducted separately in male and female subgroups.
No associations with positive symptoms were revealed. In male patients, the 2D:4D ratio was positively associated with avolition and inversely associated with anxiety. In female patients, it was inversely associated with alogia, and tended to be positively associated with depression. No association between higher prenatal concentration of the relevant sex hormone and improved neuropsychological performance emerged in patients.
Higher concentrations of prenatal testosterone in male patients, and prenatal oestrogens in female patients, are associated with a decrement in certain aspects of negative symptomatology. In addition, prenatal sex hormone concentration seems to be associated with predisposition to anxiety in male patients, and to depression in female patients.
研究表明，女性循环雌激素水平较高，男性循环睾丸激素水平较高，可对精神分裂症的临床表现（主要是阴性症状）起到保护作用。某些研究表明，它们对该疾病中观察到的神经认知损伤也具有保护作用。我们研究了女性的 2D:4D 比值（反映出更高的产前雌激素暴露水平）和男性的 2D:4D 比值（反映出更高的产前睾丸激素暴露水平）是否与降低阴性症状和改善患者的神经认知功能有关。
51 名精神分裂症患者和 50 名健康参与者接受了神经心理学测试。所有参与者均测量了 2D:4D 比值。在患者中评估了阳性、阴性和情感症状。在男性和女性亚组中分别进行了回归分析。
未发现与阳性症状有关的结果。在男性患者中，2D:4D 比值与意志减退呈正相关，与焦虑呈负相关。在女性患者中，它与言语贫乏呈负相关，且与抑郁呈正相关。患者中未出现较高的产前相关性激素浓度与改善的神经认知表现之间的关联。
男性患者的产前睾丸激素浓度较高，女性患者的产前雌激素浓度较高，与某些阴性症状的减少有关。此外，产前性激素浓度似乎与男性患者的焦虑倾向和女性患者的抑郁倾向有关。
