Takahashi Hidenori, Inoue Yuji, Tan Xue, Inoda Satoru, Sakamoto Shinichi, Arai Yusuke, Yanagi Yasuo, Fujino Yujiro, Kawashima Hidetoshi
Department of Ophthalmology, Jichi Medical University, Shimotsuke.
Department of Ophthalmology, The University of Tokyo, Bunkyo.
Clin Ophthalmol. 2018 Feb 20;12:369-375. doi: 10.2147/OPTH.S151999. eCollection 2018.
To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD).
In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch's membrane); central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]); SRF thickness (SRFT); pigment epithelium detachment thickness (PEDT); and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and the 5 parameters was examined with generalized estimating equations.
CMT, CRT, and CCT were negatively correlated with logMAR BCVA (=0.031, 0.023, and 0.036, respectively) when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-μm reduction in CMT, CRT, or CCT improved logMAR BCVA by -0.1, -0.08, or -0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 μm.
Dry macula with CMT <230 μm was associated with temporary decrease in visual acuity in AMD patients whose visual acuity was maintained with PRN regimen.
研究湿性年龄相关性黄斑变性（AMD）患者的视力与中心黄斑厚度（CMT）及脉络膜厚度（CCT）之间的相关性。
在这项回顾性分析中，对14只接受了超过10次雷珠单抗注射（基于按需[PRN]方案）并维持初始视力提高的眼睛进行了分析。在黄斑中心测量以下5个参数：CMT（从内界膜[ILM]到布鲁赫膜的距离）；中心视网膜厚度（CRT；从ILM到视网膜色素上皮内界或视网膜下液[SRF]的距离）；SRF厚度（SRFT）；色素上皮脱离厚度（PEDT）；以及CCT。使用广义估计方程检验最小分辨角对数（logMAR）最佳矫正视力（BCVA）与这5个参数之间的相关性。
当仅使用每只眼睛中小于使视力最大化的厚度的CMT值进行分析时，CMT、CRT和CCT与logMAR BCVA呈负相关（分别为=0.031、0.023和0.036）。CMT、CRT或CCT每减少100μm，logMAR BCVA分别提高-0.1、-0.08或-0.07。SRFT和PEDT与BCVA无关。使视力最大化的CMT中位数为230μm。
在采用PRN方案维持视力的AMD患者中，CMT<230μm的干性黄斑与视力暂时下降有关。
