Naber J M, Huether C A, Goodwin B A
Prenat Diagn. 1987;7(1):51-65. doi: 10.1002/pd.1970070109.
The history of amniocentesis utilization in the seventh largest state of the United States is documented from its inception in 1972 through the first half of 1984. Amniocentesis utilization ratios for Ohio residents aged greater than or equal to 35 have increased from 0.21 per cent (19/9091) in 1972 to 23.4 per cent (1655/7531) in 1983, representing an average annual growth rate of 43.1 per cent. Of the amniocenteses performed from January 1, 1978-July 1, 1984, 71 per cent were referred for advanced maternal age (greater than or equal to 35), 15 per cent for maternal anxiety (30-34), 10 per cent for family history or previous child with a genetic defect, and 4 per cent for other reasons. Between 1978-1983 utilization by women 45 years of age was only 20 per cent higher than women 35 even though their risk of giving birth to a Down syndrome child was bout one order of magnitude higher. In addition, various factors were tested as to whether they affected utilization of amniocentesis by women greater than or equal to 35 during 1978-1983. A strong correlation of +0.89 existed between county population size and utilization ratios. No difference in utilization was found between whites and nonwhites, regardless of county population size. When utilization ratios were compared separately between Protestants, Catholics and other religions in Ohio's most populated county, no statistical differences were found. From 1978-July 1, 1984, the frequency of all cytogenetically abnormal chromosome results observed in Ohio amniocenteses to women greater than or equal to 35 was 2.48 per cent (187/7536). Of these, 2.15 per cent (162/7536) had unbalanced karyotypes. Future maximum amniocentesis utilization for women greater than or equal to 35 is estimated at 60-70 per cent.
记录了美国第七大州自1972年开始至1984年上半年羊膜穿刺术的使用历史。俄亥俄州年龄大于或等于35岁居民的羊膜穿刺术使用率从1972年的0.21%（19/9091）增至1983年的23.4%（1655/7531），年均增长率为43.1%。在1978年1月1日至1984年7月1日进行的羊膜穿刺术中，71%因孕妇年龄偏大（大于或等于35岁）而进行，15%因孕妇焦虑（30 - 34岁），10%因家族病史或之前的孩子有遗传缺陷，4%因其他原因。1978 - 1983年间，45岁女性的使用率仅比35岁女性高20%，尽管她们生育唐氏综合征患儿的风险约高一个数量级。此外，对1978 - 1983年间大于或等于35岁女性羊膜穿刺术使用情况的各种影响因素进行了测试。县人口规模与使用率之间存在+0.89的强相关性。无论县人口规模如何，白人和非白人在使用率上没有差异。在俄亥俄州人口最多的县，分别比较新教徒、天主教徒和其他宗教人群的使用率时，未发现统计学差异。1978年至1984年7月1日，俄亥俄州大于或等于35岁女性羊膜穿刺术所有细胞遗传学异常染色体结果的发生率为2.48%（187/7536）。其中，2.15%（162/7536）有核型不平衡。大于或等于35岁女性未来羊膜穿刺术的最大使用率估计为60 - 70%。
