子宫肌瘤的体素内不相干运动模型组织特征：T 校正的必要性。
Tissue characterization of uterine fibroids with an intravoxel incoherent motion model: The need for T correction.
机构信息
Department of Physics, University of Houston, Houston, Texas, USA.
Texas Center for Superconductivity, Houston, Texas, USA.
出版信息
J Magn Reson Imaging. 2018 Oct;48(4):994-1001. doi: 10.1002/jmri.25988. Epub 2018 Mar 5.
BACKGROUND
Diminished signal intensity of uterine fibroids in T -weighted images is routinely used as a qualitative marker of fibroid hypoperfusion. However, quantitative classification of fibroid perfusion with intravoxel incoherent motion (IVIM) model-based metrics is not yet clinically accepted.
PURPOSE
To investigate the influence of T correction on the estimation of IVIM model parameters for characterizing uterine fibroid tissue.
STUDY TYPE
Prospective.
POPULATION
Fourteen women with 41 fibroids (12 Type I and 29 Type II, per Funaki classification) underwent diffusion-weighted imaging and T mapping.
FIELD STRENGTH
Diffusion-weighted images (b values: 0, 20, 40, 60, 100, 200, 400, 600, 800, 1000 s/mm ) and T maps were obtained at 1.5T.
ASSESSMENT
The effect of uterine fibroid T variation on IVIM model parameters (diffusion coefficient, perfusion coefficient, and perfusion volume fraction) were numerically modeled and experimentally evaluated without (D, D*, f) and with (D , , f ) T correction. The relationship of T with D and the T -corrected perfusion volume fraction (f ) was also examined.
STATISTICAL TEST
D-values and f-values estimated with and without T correction were compared by using a two-tailed Student's t-test.
RESULTS
Type II fibroids had higher D and f than Type I fibroids, but the differences were not significant (Type I vs. Type II, D: 0.83 ± 0.20 vs. 0.80 ± 0.25 mm /s, P = 0.78; f: 23.64 ± 4.87% vs. 25.27 ± 7.46%, P = 0.49). For Type I and Type II fibroids, f was lower than f, and f of Type II fibroids was significantly higher than that of Type I fibroids (Type I vs. Type II, f : 7.80 ± 1.88% vs. 11.82 ± 4.13%, P = 0.003). Both D and f exponentially increased with the increase of fibroid T as functions: and respectively. D asymptotically approached 1.79 × 10 mm /s, and f approached 21.74%.
DATA CONCLUSION
T correction is important when using IVIM-based models to characterize uterine fibroid tissue.
LEVEL OF EVIDENCE
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:994-1001.
背景
T 加权图像中子宫肌瘤信号强度的降低通常被用作子宫肌瘤低灌注的定性标志物。然而，基于体素内不相干运动（IVIM）模型的定量分类方法尚未在临床上得到认可。
目的
探讨 T 校正对子宫肌瘤组织 IVIM 模型参数特征描述的影响。
研究类型
前瞻性。
人群
14 名女性，共 41 个子宫肌瘤（12 个 I 型，29 个 II 型，按 Funaki 分类），行扩散加权成像和 T 映射。
磁场强度
在 1.5T 下获得扩散加权图像（b 值：0、20、40、60、100、200、400、600、800、1000 s/mm ）和 T 图。
评估
通过数值模拟和实验评估了不考虑（D、D*、f）和考虑（D*、D*、f）T 校正时，子宫肌瘤 T 变化对 IVIM 模型参数（扩散系数、灌注系数和灌注容积分数）的影响。还检查了 T 与 D 和 T 校正后的灌注容积分数（f）之间的关系。
统计检验
使用双侧学生 t 检验比较 T 校正前后的 D 值和 f 值。
结果
与 I 型子宫肌瘤相比，II 型子宫肌瘤的 D 和 f 值更高，但差异无统计学意义（I 型 vs. II 型，D：0.83±0.20 vs. 0.80±0.25 mm/s，P=0.78；f：23.64±4.87% vs. 25.27±7.46%，P=0.49）。对于 I 型和 II 型子宫肌瘤，f 低于 f，II 型子宫肌瘤的 f 明显高于 I 型子宫肌瘤（I 型 vs. II 型，f：7.80±1.88% vs. 11.82±4.13%，P=0.003）。D 和 f 均随肌瘤 T 的增加呈指数增加，函数分别为和。D 逐渐接近 1.79×10 mm/s，f 接近 21.74%。
数据结论
在使用基于 IVIM 的模型对子宫肌瘤组织进行特征描述时，T 校正很重要。
证据水平
2 级，技术功效，第 1 阶段。磁共振成像杂志，2018 年；48：994-1001。
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