Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
J Magn Reson Imaging. 2019 Jan;49(1):118-130. doi: 10.1002/jmri.26221. Epub 2018 Sep 20.
As both intravoxel incoherent motion (IVIM) modeling and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide perfusion parameters, IVIM-derived perfusion parameters might be expected to correlate with the kinetic features from DCE-MRI.
To investigate the association between IVIM parameters and prognostic factors and to evaluate the correlation between IVIM parameters and kinetic features in invasive breast cancer patients using computer-aided diagnosis (CAD).
Retrospective.
Eighty-five patients (invasive cancers; mean size, 1.8 cm; range, 0.8-4.8 cm) who underwent diffusion-weighted imaging with 12 b-values (0-1000 s/mm ).
FIELD STRENGTH/SEQUENCE: 3.0T MRI axial, IVIM-DWI epi-sequence, and DCE-MRI.
Two radiologists measured the apparent diffusion coefficient (ADC), diffusion coefficient, pseudodiffusion coefficient, and perfusion fraction (f) using IVIM modeling. Kinetic features such as peak enhancement and early and delayed enhancement profiles were acquired using CAD.
The correlation between the IVIM parameters and kinetic features and the association between the IVIM parameters and prognostic factors were investigated using Mann-Whitney test and Spearman correlation test.
There were no significant associations between IVIM parameters and prognostic factors. When IVIM parameters were correlated with kinetic features by CAD, both the ADC and f values showed correlations with delayed enhancement profiles. The ADC values were lower in tumors with lower persistent components (P = 0.013) and higher washout components (P = 0.045) and showed a positive correlation with persistent proportion (Spearman's rho (r) = 0.222, P = 0.041). The f value was higher in tumors with higher persistent components (P = 0.021) and showed a positive correlation with persistent proportion (r = 0.227, P = 0.029).
This analysis revealed that IVIM-derived ADC and f values showed correlations with kinetic features at the delayed phase as assessed by CAD. These results indicate the potential of IVIM imaging biomarkers to provide information on the biological and kinetic properties of breast cancers without a contrast agent.
4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:118-130.
体素内不相干运动（IVIM）建模和动态对比增强磁共振成像（DCE-MRI）均可提供灌注参数，因此 IVIM 衍生的灌注参数可能与 DCE-MRI 的动力学特征相关。
利用计算机辅助诊断（CAD），探讨 IVIM 参数与预后因素的相关性，并评估浸润性乳腺癌患者 IVIM 参数与动力学特征的相关性。
回顾性研究。
85 例患者（浸润性癌；平均大小为 1.8cm；范围 0.8-4.8cm），均行扩散加权成像，共 12 个 b 值（0-1000s/mm）。
磁场强度/序列：3.0T MRI 轴位，IVIM-DWI epi 序列，DCE-MRI。
两位放射科医生使用 IVIM 模型分别测量表观扩散系数（ADC）、扩散系数、假性扩散系数和灌注分数（f）。使用 CAD 获得峰增强和早期及延迟增强轮廓等动力学特征。
采用 Mann-Whitney 检验和 Spearman 相关检验，分析 IVIM 参数与动力学特征的相关性，以及 IVIM 参数与预后因素的相关性。
IVIM 参数与预后因素之间无显著相关性。当通过 CAD 将 IVIM 参数与动力学特征相关联时，ADC 和 f 值均与延迟增强轮廓相关。ADC 值在低持续成分（P=0.013）和高洗脱成分（P=0.045）的肿瘤中较低，与持续比例呈正相关（Spearman's rho（r）=0.222，P=0.041）。f 值在高持续成分（P=0.021）的肿瘤中较高，与持续比例呈正相关（r=0.227，P=0.029）。
本分析表明，IVIM 衍生的 ADC 和 f 值与 CAD 评估的延迟期动力学特征具有相关性。这些结果表明，IVIM 成像生物标志物有可能在不使用造影剂的情况下提供有关乳腺癌生物学和动力学特性的信息。
4 级，技术功效，2 期。J. Magn. Reson. Imaging 2019；49：118-130。
