Hoseini R F, Jabbari F, Rezaee A, Rafatpanah H, Yousefzadeh H, Ariaee N, Sadri H
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Biol Regul Homeost Agents. 2018 Jan-Feb;32(1):83-88.
Sensitivity to house dust mite allergens in the development of allergic rhinitis has a key role. In this study, the clinical and immunological effects of high dose Dermatophagoides farinae sublingual immunotherapy (SLIT) versus placebo were compared. Forty poly-sensitized patients, ages 6-33 years, with allergic rhinitis and positive allergic reaction to the mites were enrolled in the study. Twenty-one patients were placed in the SLIT group and 19 in the placebo group. Expression levels of IL-10, TGF-β, FOXP3 and IL-17 were measured by using real-time PCR before and after the administration of sublingual immunotherapy. Clinical efficacy was estimated by the reduction rate of symptom/medication scores in the SLIT group compared with placebo treatment. After 6 months of SLIT, TGF-β expression levels were increased compared to pre-treatment (P less than 0.05). SLIT with D. Farinae extract is an effective treatment for poly-sensitized patients with allergic rhinitis. TGF-β mediated T-cell suppression may be an important mechanism in the first 6 months of SLIT.
对屋尘螨过敏原的敏感性在变应性鼻炎的发病过程中起关键作用。在本研究中，比较了高剂量粉尘螨舌下免疫疗法（SLIT）与安慰剂的临床和免疫学效果。40例年龄在6至33岁之间、患有变应性鼻炎且对螨虫过敏反应呈阳性的多敏患者被纳入研究。21例患者被纳入SLIT组，19例被纳入安慰剂组。在舌下免疫疗法给药前后，通过实时PCR测量IL-10、TGF-β、FOXP3和IL-17的表达水平。通过与安慰剂治疗相比，SLIT组症状/用药评分的降低率来评估临床疗效。SLIT治疗6个月后，与治疗前相比，TGF-β表达水平升高（P小于0.05）。粉尘螨提取物舌下免疫疗法是治疗多敏性变应性鼻炎患者的有效方法。TGF-β介导的T细胞抑制可能是舌下免疫疗法前6个月的重要机制。
