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Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: results of monotherapy and combination therapy trials.

作者信息

Alecu Iulian, Milenkova Tsveta, Turner Simon R

机构信息

Research and Development, AstraZeneca UK Limited, Cambridge, UK.

出版信息

Drug Des Devel Ther. 2018 Feb 21;12:347-348. doi: 10.2147/DDDT.S156746. eCollection 2018.

DOI:10.2147/DDDT.S156746
PMID:29505040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5826089/
Abstract
摘要

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本文引用的文献

1
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials.接受聚(ADP - 核糖)聚合酶(PARP)抑制剂治疗的癌症患者发生严重血液学毒性的风险:一项随机对照试验的荟萃分析。
Drug Des Devel Ther. 2017 Oct 13;11:3009-3017. doi: 10.2147/DDDT.S147726. eCollection 2017.
2
Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial.奥拉帕利片作为 BRCA1/2 突变的铂敏感复发性卵巢癌患者的维持治疗(SOLO2/ENGOT-Ov21):一项双盲、随机、安慰剂对照、III 期临床试验。
Lancet Oncol. 2017 Sep;18(9):1274-1284. doi: 10.1016/S1470-2045(17)30469-2. Epub 2017 Jul 25.
3
Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation.奥拉帕利治疗携种系 BRCA 突变的转移性乳腺癌患者。
N Engl J Med. 2017 Aug 10;377(6):523-533. doi: 10.1056/NEJMoa1706450. Epub 2017 Jun 4.