Frol'kis V V, Verkhratskiĭ N S, Magdich L V
Probl Endokrinol (Mosk). 1987 Jan-Feb;33(1):63-6.
The experiments performed on mature (4-6) and old (28-30 months) rats revealed changes developed in old animals in various links of regulatory system of aldosterone secretion: the decreased hypothalamohypophyseal control of mineralocorticoid secretion, increased sensitivity of glomerular zone to ACTH, vasopressin, K+ and of myocardium skeletal muscle and renal tissue to aldosterone. Changes in tissue sensitivity to aldosterone may be conditioned by the increased affinity of mineralocorticoid receptors to aldosterone in old age.
对成年（4 - 6个月）和老年（28 - 30个月）大鼠进行的实验揭示了老年动物醛固酮分泌调节系统各个环节出现的变化：下丘脑 - 垂体对盐皮质激素分泌的控制减弱，肾小球带对促肾上腺皮质激素、血管加压素、钾离子的敏感性增加，心肌、骨骼肌和肾组织对醛固酮的敏感性增加。组织对醛固酮敏感性的变化可能是由于老年时盐皮质激素受体对醛固酮的亲和力增加所致。
