一例罕见的氧氟沙星所致中毒性表皮坏死松解症病例报告。
A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin.
作者信息
Vaghela Jhanvi J, Nimbark Vivek N, Chavda Bhavesh C, Mehta Hita H, Purohit Bhargav M
机构信息
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar - 364001, Gujarat, India.
Department of Dermatology, Venereology & Leprosy, Government Medical College & Sir Takhtsinhji General Hospital Bhavnagar, Gujarat, India.
出版信息
Curr Drug Saf. 2018;13(2):137-140. doi: 10.2174/1574886313666180302124012.
BACKGROUND
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, are rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet unclear.
CASE REPORT
A 45-year-old male patient by chance on re-exposure to Ofloxacin developed Severe Cutaneous Adverse Drug Reaction (SCADR), diagnosed with toxic epidermal necrolysis. His comorbid conditions and systemic complications of TEN lead him to death. In developing countries, where antibiotics especially fluoroquinolones are widely prescribed, a physician should be now vigilant for such kind of SCADRs because of increasing numbers of such kind of reports.
背景
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN），也称为莱尔综合征，是罕见的危及生命的疾病，其发病机制以及药物治疗尚不清楚。
病例报告
一名45岁男性患者再次接触氧氟沙星后偶然发生严重皮肤药物不良反应（SCADR），被诊断为中毒性表皮坏死松解症。他的合并症和TEN的全身并发症导致了他的死亡。在抗生素尤其是氟喹诺酮类药物广泛使用的发展中国家，由于此类报告数量不断增加，医生现在应对此类SCADR保持警惕。
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