Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei, 061001, China.
Department of Otolaryngology, Cangzhou Medical College, Cangzhou, Hebei, 061001, China.
World J Surg Oncol. 2018 Mar 5;16(1):44. doi: 10.1186/s12957-018-1350-5.
The study aims to find out independent prognostic factors for patients with malignant peritoneal mesothelioma (MPeM).
Patients with pathologically proven MPeM were retrospectively reviewed. Potential prognostic factors were analyzed, including age, gender, asbestos exposure, body mass index (BMI), treatment, and laboratory results, such as blood routine examination and liver functions. The influences of various risk factors on the prognoses were analyzed by univariate analysis. A Cox regression model analysis established independent factors for the survival prognosis of the patients.
Seventy MPeM patients, including 33 patients who received intraperitoneal chemotherapy with cisplatin, 14 patients who received systemic chemotherapy with cisplatin + pemetrexed, and 21 untreated patients were included in this study. The 1-year survival was 32.9%, the 2-year survival was 10%, and the 3-year survival was 2.9%. The median age of MPeM was 62 years, and the female-to-male ratio was 1:0.56. The univariate and multivariate analyses showed that treatment, albumin (ALB), and blood neutrophil-to-lymphocyte ratio (NLR) were independent factors that affected the overall survival (OS) of MPeM patients.
High blood NLR and hypoalbuminemia are adverse prognostic factors for MPeM patients. Systemic chemotherapy and intraperitoneal chemotherapy can prolong the survival period.
本研究旨在探讨恶性腹膜间皮瘤（MPeM）患者的独立预后因素。
回顾性分析经病理证实的 MPeM 患者。分析潜在的预后因素，包括年龄、性别、石棉暴露、体重指数（BMI）、治疗和实验室结果，如血常规检查和肝功能。通过单因素分析，分析各种危险因素对预后的影响。Cox 回归模型分析确立了影响患者生存预后的独立因素。
本研究共纳入 70 例 MPeM 患者，其中接受顺铂腹腔化疗的患者 33 例，接受顺铂+培美曲塞全身化疗的患者 14 例，未治疗的患者 21 例。1 年生存率为 32.9%，2 年生存率为 10%，3 年生存率为 2.9%。MPeM 患者的中位年龄为 62 岁，男女比例为 1:0.56。单因素和多因素分析表明，治疗、白蛋白（ALB）和血中性粒细胞与淋巴细胞比值（NLR）是影响 MPeM 患者总生存期（OS）的独立因素。
高血 NLR 和低白蛋白血症是 MPeM 患者的不良预后因素。全身化疗和腹腔化疗可以延长生存期。
