Larsen Carsten Schade, Katzenstein Terese L
Ugeskr Laeger. 2018 Feb 26;180(9).
Primary antibody deficiencies (PAD) make up more than half of primary immunodeficiencies. PAD is characterized by low levels of one or more immunoglobulin (Ig) classes or impaired vaccine response. Recurrent infections are the predominant presenting symptoms, but autoimmune disorders are also frequent. Onset of symptoms is often after the age of six. Screening for PAD with measurement of the levels of serum IgG, IgM, and IgA is simple and can be done in general practice. Replacement therapy with Ig is the cornerstone in treatment of PAD and reduces the frequency of infections and mortality.
原发性抗体缺陷（PAD）占原发性免疫缺陷的一半以上。PAD的特征是一种或多种免疫球蛋白（Ig）类水平低下或疫苗反应受损。反复感染是主要的临床表现，但自身免疫性疾病也很常见。症状通常在6岁以后出现。通过检测血清IgG、IgM和IgA水平来筛查PAD很简单，在普通诊所即可进行。免疫球蛋白替代疗法是PAD治疗的基石，可降低感染频率和死亡率。
