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慢性术后胸骨感染的延迟诊断:一例罕见的胸骨结核病例

Delayed diagnosis of chronic postoperative sternal infection: a rare case of sternal tuberculosis.

作者信息

Rizzo Victoria, Salmasi Yousuf, Hunter Michael, Sidhu Pushpinder

机构信息

Cardiothoracic Surgery, Belfast Health and Social Care Trust, Royal Victoria Hospital, Belfast, UK.

Infectious Disease Unit, Belfast Health and Social Care Trust, Royal Victoria Hospital, Belfast, UK.

出版信息

BMJ Case Rep. 2018 Mar 5;2018:bcr-2017-223650. doi: 10.1136/bcr-2017-223650.

Abstract

Sternal osteomyelitis secondary to mycobacterium tuberculosis (TB) is rare, with <1% of musculoskeletal TB cases reported. The recurrent scenario is unresolving infection and delayed diagnosis. A 75-year-old woman presented with a persistently discharging sternal wound 10 months after coronary artery bypass grafting. Multiple antibiotics, wound debridement and removal of sternal wires was attempted; however, progression to local osteomyelitis and sternoclavicular joint destruction occurred. Tissue biopsies were finally sent for mycobacterial culture testing positive for High index of suspicion is necessary for diagnosis of sternal tuberculosis, confirmed through timely microbiological investigations. MRI may identify soft-tissue and bone oedema characteristic of TB osteomyelitis. This patient had no TB risk factors. The source of infection is unclear and warrants further investigation. Sternal TB osteomyelitis is uncommon and largely reported through case reports, thus management and indications for surgery remain undefined. If sensitive, standard TB four-drug regimen may be trialled.

摘要

继发于结核分枝杆菌(TB)的胸骨骨髓炎较为罕见,在报告的肌肉骨骼结核病例中占比不到1%。反复出现的情况是感染无法解决且诊断延迟。一名75岁女性在冠状动脉搭桥术后10个月出现胸骨伤口持续流脓。尝试了多种抗生素治疗、伤口清创和胸骨钢丝取出;然而,病情进展为局部骨髓炎和胸锁关节破坏。最终进行组织活检,结核分枝杆菌培养检测呈阳性。对胸骨结核的诊断需要高度怀疑指数,并通过及时的微生物学检查来确诊。MRI可能会发现结核性骨髓炎特有的软组织和骨水肿。该患者没有结核风险因素。感染源不明,需要进一步调查。胸骨结核性骨髓炎并不常见,大多通过病例报告报道,因此手术的管理和指征仍不明确。如果敏感,可以尝试使用标准的四联抗结核药物治疗方案。

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