Daya S, Rosenthal K L, Clark D A
Am J Obstet Gynecol. 1987 Feb;156(2):344-50. doi: 10.1016/0002-9378(87)90281-x.
Mechanisms that explain failure of rejection of the antigenic fetus by the mother appear to lie at the fetomaternal interface. Successful pregnancies have been correlated with the presence of decidua-associated suppressor cells. Supernatants from these cells were tested for their ability to suppress the proliferation of interleukin 2-dependent cells and were also subjected to high-performance liquid chromatography. Decidual supernatant was found to have peak suppressive activity at two molecular weights (43,000 and 21,000 daltons). The activity of decidual supernatant was directed specifically at interleukin 2-dependent cells and interfered with interleukin 2 action. The importance of this mechanism in graft rejection is well known. Decidual supernatant may thus prevent fetal allograft rejection by preventing the maternal cytotoxic effectors from receiving the interleukin 2-dependent help that they need to proliferate and remain actively cytolytic.
母体无法排斥具有抗原性的胎儿，其机制似乎存在于母胎界面。成功妊娠与蜕膜相关抑制细胞的存在有关。检测了这些细胞的上清液抑制白细胞介素2依赖性细胞增殖的能力，并对其进行了高效液相色谱分析。发现蜕膜上清液在两个分子量（43,000和21,000道尔顿）处具有峰值抑制活性。蜕膜上清液的活性特异性针对白细胞介素2依赖性细胞，并干扰白细胞介素2的作用。这种机制在移植排斥中的重要性是众所周知的。因此，蜕膜上清液可能通过阻止母体细胞毒性效应物获得其增殖和保持活跃细胞溶解所需的白细胞介素2依赖性辅助，从而防止胎儿同种异体移植排斥。
