[ATP-P2XR信号通路及其在寄生虫病中的作用]
[ATP-P2XR signalling pathway and its effects in parasitic diseases].
作者信息
Wang-Fang J, Chun-Jie J, Fei G, Jia-Hui L, Ming L
机构信息
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Clinical Laboratory, Changzhi People's Hospital, China.
Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017 Jul 24;29(4):526-529. doi: 10.16250/j.32.1374.2016250.
ATP (Adenosine triphosphate) is an important endogenous damage - associated molecular pattern (DAMP). P2XR is an ATP-gated cation channel. ATP-P2XR plays a vital role in the pathophysiology of many diseases because P2XR is distributed on various immune cells. ATP-P2XR signal transduction pathway has been implicated to participate in the body's immune defense against pathogens. This paper reviews the recent progress regarding ATP-P2XR and its effects on parasitic diseases.
三磷酸腺苷（ATP）是一种重要的内源性损伤相关分子模式（DAMP）。P2XR是一种ATP门控阳离子通道。由于P2XR分布于多种免疫细胞上，ATP-P2XR在许多疾病的病理生理学中起着至关重要的作用。ATP-P2XR信号转导通路已被认为参与机体对病原体的免疫防御。本文综述了关于ATP-P2XR及其对寄生虫病影响的最新研究进展。
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