Cumano A, Vieira P, Colle J H, Truffa-Bachi P, Freitas A
Ann Inst Pasteur Immunol. 1986 Nov-Dec;137D(3):355-67.
In the present work, we investigate the effects of hydroxyurea (HU) treatment given before antigen priming on the antibody response in the mouse. We have studied the response to both thymus-independent and thymus-dependent antigens. With both types of antigens, we have found a two- to ten-fold increase in the number of antigen-specific IgM PFC in the spleens of HU-treated primed mice. In the case of the T-dependent antigens, a simultaneous decrease in the IgG PFC response was also observed in HU-treated mice. These results suggest that major changes in the dynamic equilibrium of the cells of the immune system, induced by HU treatment, may result in different homeostatic regulation, as revealed by the modified pattern of response to exogenous antigens.
在本研究中，我们调查了在抗原致敏前给予羟基脲（HU）处理对小鼠抗体反应的影响。我们研究了对非胸腺依赖性和胸腺依赖性抗原的反应。对于这两种类型的抗原，我们发现经HU处理的致敏小鼠脾脏中抗原特异性IgM形成细胞（PFC）的数量增加了2至10倍。对于胸腺依赖性抗原，在经HU处理的小鼠中还同时观察到IgG PFC反应的降低。这些结果表明，HU处理诱导的免疫系统细胞动态平衡的主要变化可能导致不同的稳态调节，这通过对外源抗原反应模式的改变得以揭示。
