Kashimata M, Hiramatsu M, Minami N
Biochim Biophys Acta. 1987 Mar 19;923(3):496-500. doi: 10.1016/0304-4165(87)90059-6.
The effect of streptozotocin-induced diabetes on 125I-labeled epidermal growth factor (EGF) binding was studied in microsomal membranes from rat liver. The binding of EGF in membranes from diabetic animals was significantly low, the value being about 60% of the control level. Scatchard analysis of the binding data clearly showed that the decrease in EGF binding was due to a decrease in the number of receptors. Treatment of diabetic animals with insulin restored EGF receptors to control levels, whereas the treatment with triiodothyronine had no effect. Serum EGF concentrations measured were almost the same among the control, diabetic, and insulin-treated diabetic groups. These results suggest that insulin deficiency in vivo causes a decrease in hepatic EGF receptors.
研究了链脲佐菌素诱导的糖尿病对大鼠肝脏微粒体膜中125I标记的表皮生长因子（EGF）结合的影响。糖尿病动物膜中EGF的结合显著降低，该值约为对照水平的60%。对结合数据的Scatchard分析清楚地表明，EGF结合的减少是由于受体数量的减少。用胰岛素治疗糖尿病动物可使EGF受体恢复到对照水平，而用三碘甲状腺原氨酸治疗则无效。在对照、糖尿病和胰岛素治疗的糖尿病组中测得的血清EGF浓度几乎相同。这些结果表明，体内胰岛素缺乏会导致肝脏EGF受体减少。
