[Specific lesions of serotoninergic cells in the raphe. Effect on kindling of the olfactory bulb in rats].

Limbic kindling obtained by electrical stimulation of the olfactory bulb in the rat has been studied after specific lesion of serotonergic cells in mesencephalic and pontic raphe nuclei with local microinjection of 5,7-dihydroxytryptamine. The extent of the raphe lesions was verified by immunocytochemical technics with antiserotonin antibody. Lesioned rats showed an increase of kindling rate, which confirms the inhibitory function of serotonin in the development of this phenomenon.