Nováčková M, Pastor Z, Matěcha J, Čekal M, Froněk J, Chmel R
Ceska Gynekol. 2018 Winter;83(1):62-68.
Evaluation of pregnancies and deliveries in women after solid organ transplantations with respect to the maternal and fetal risks.
Overview article.
Department of Obstetrics and Gynaecology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague.
Literature search using the Web of Science, Ovid, Cochrane, Google Scholar and Medline databases with keywords (transplantation, pregnancy, immunosuppression) and analysis of articles published in impact and reviewed journals from 1958 to 2017.
Pregnancy in patients after solid organ transplantions is associated with the higher risk of complications, particularly preeclampsia, and high incidence of comorbidities. Women after transplantation have an increased risk of premature deliveries and low birth weight newborns. The highest risk of complications is documented after lung transplantation. For immunosuppression in pregnancy inhibitors of calcineurin, azathioprine and prednisone are used.
Pregnancies and deliveries in women after solid organ transplants are in a high risk. With early transplantation, adequate patient health compensation, properly planned pregnancy, adequate immunosuppressive therapy and specialized prenatal and obstetric care, women can give birth to healthy newborns after transplantation.
评估实体器官移植术后女性的妊娠和分娩情况，关注母婴风险。
综述文章。
布拉格查理大学医学院第二附属医院妇产科及莫托勒大学医院。
使用科学网、Ovid、Cochrane、谷歌学术和Medline数据库，以关键词（移植、妊娠、免疫抑制）进行文献检索，并分析1958年至2017年在有影响力和经过同行评审的期刊上发表的文章。
实体器官移植术后患者妊娠与并发症风险较高相关，尤其是子痫前期，且合并症发生率高。移植术后女性早产和低体重新生儿的风险增加。肺移植后并发症风险最高。妊娠期免疫抑制使用钙调神经磷酸酶抑制剂、硫唑嘌呤和泼尼松。
实体器官移植术后女性的妊娠和分娩风险很高。通过早期移植、充分的患者健康代偿、合理规划妊娠、适当的免疫抑制治疗以及专业的产前和产科护理，女性移植后可以生出健康的新生儿。
