Department of General Surgery, Yantai Shan Hospital, Yantai, Shandong 264000, P.R. China.
Department of Bone Tumor, Yantai Shan Hospital, Yantai, Shandong 264000, P.R. China.
Int J Mol Med. 2018 Jun;41(6):3167-3174. doi: 10.3892/ijmm.2018.3520. Epub 2018 Feb 28.
Gastric cancer (GC) is the second most common cause of cancer-related deaths. In recent years some essential factors for resolution were identified, but the clinical trials still lack the effective methods to treat or monitor the disease progression. Regenerating islet-derived 3α (REG3A) is a member of REG protein family. Previous studies have investigated the altered expression of REG3A in various cancers. In this investigtion we aimed at the biological function and the underlying molecular mechanism of REG3A in GC. We found that REG3A was significantly downregulated in GC and closely related with patient prognoses. REG3A overexpression suppressed the invasion and proliferation promoting apoptosis of GC cells. While REG3A knockdown promoted the invasion, and proliferation suppressing apoptosis of GC cells. It was further found that REG3A performed its biological functions mainly through phosphatidylinositol 3 kinase (PI3K)/Akt-GSK3β signaling pathway axis. REG3A may be a promising therapeutic strategy for GC.
胃癌（GC）是癌症相关死亡的第二大主要原因。近年来，一些对于解决 GC 的关键因素已被确定，但临床研究仍然缺乏有效治疗或监测疾病进展的方法。再生胰岛衍生 3α（REG3A）是 REG 蛋白家族的一员。先前的研究已经调查了 REG3A 在各种癌症中的表达变化。在这项研究中，我们旨在研究 REG3A 在 GC 中的生物学功能和潜在的分子机制。我们发现 REG3A 在 GC 中显著下调，与患者预后密切相关。REG3A 的过表达抑制了 GC 细胞的侵袭和增殖，促进了细胞凋亡。而 REG3A 的敲低则促进了 GC 细胞的侵袭和增殖，抑制了细胞凋亡。进一步研究发现，REG3A 通过磷酸肌醇 3 激酶（PI3K）/Akt-GSK3β 信号通路轴发挥其生物学功能。REG3A 可能是 GC 的一种有前途的治疗策略。
