电化学 C-O 键形成：芳香内酯的简便合成方法。
Electrochemical C-O Bond Formation: Facile Access to Aromatic Lactones.
机构信息
School of Biological and Medical Engineering, Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, Hefei University of Technology, Hefei, 230009, P.R. China.
出版信息
Chemistry. 2018 May 11;24(27):6932-6935. doi: 10.1002/chem.201801108. Epub 2018 Apr 20.
An efficient and robust methodology based on electrochemical techniques for the direct synthesis of aromatic lactones through dehydrogenative C-O cyclization is described. This new and useful electrochemical reaction can tolerate a variety of functional groups, and is scalable to 100 g under mild conditions. Remarkably, heterocycle-containing substrates can be employed, thus expanding the scope of radical C-O cyclization reactions.
本文描述了一种基于电化学技术的高效、稳健的方法，用于通过脱氢 C-O 环化直接合成芳族内酯。这种新的有用的电化学反应可以容忍多种官能团，并且可以在温和条件下扩大到 100g。值得注意的是，含有杂环的底物也可以被应用，从而扩展了自由基 C-O 环化反应的范围。
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