Carbon Dioxide Activation Center (CADIAC), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus (Denmark) http://www.skrydstrup-group.com.
Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6862-6. doi: 10.1002/anie.201500233. Epub 2015 Apr 23.
The first organocatalyzed trapping of CO2 through C-C and C-O bond formation is reported. Alkynyl indoles together with catalytic amounts of an organic base and five equivalents of CO2 resulted in the formation new heterocyclic structures. These tricyclic indole-containing products were successfully prepared under mild reaction conditions from aromatic, heteroaromatic, and aliphatic alkynyl indoles with complete regioselectivity. Further investigations suggest that C-C bond formation is the initial intermolecular step, followed by lactone-forming C-O bond formation.
首次报道了通过 C-C 和 C-O 键形成的有机催化捕获 CO2。炔基吲哚与催化量的有机碱和五当量的 CO2 一起反应，生成了新的杂环结构。这些三环吲哚类产物可以在温和的反应条件下，从芳香族、杂芳香族和脂肪族炔基吲哚中以完全区域选择性制备。进一步的研究表明，C-C 键的形成是初始的分子间步骤，随后是内酯形成的 C-O 键形成。
