Gianesini Sergio, Sisini Francesco, Menegatti Erica, Di Domenico Giovanni, Gambaccini Mauro, Occhionorelli Savino, Zamboni Paolo
1 Vascular Disease Center, Unit of Translational Surgery, University of Ferrara, Ferrara, Italy.
2 Department of Physics and Earth Sciences, University of Ferrara, Ferrara, Italy.
Phlebology. 2019 Feb;34(1):17-24. doi: 10.1177/0268355518762854. Epub 2018 Mar 7.
In physiology, velocity of the deep venous compartment is higher than the one in the saphenous compartment which is higher than the one in the tributaries. Considering that velocity variation is associated with changes in the pressure gradient, aim of the present study is to assess changes in venous kinetics in case of superficial chronic venous disease, so to provide further clues in venous drainage direction determination.
Venous ultrasound scanning was performed on 40 lower limbs of 28 chronic venous disease patients (C2-6Ep,As,Pr). Velocities were measured in three different venous segments: great saphenous vein at 2 cm above the origin of the incompetent tributary (Group-A). great saphenous vein at 2 cm below the origin of tributary (Group-B). tributary at 2 cm from its origin from the great saphenous vein (Group-C.).
Diastolic time average velocity was higher in group-C (-21.3 ± 8.5 cm/s) than in group-A (-15.7 ± 5.2 cm/s; p = .0001) and group-B (-11.1 ± 2.9 cm/s; p = .0001), thus indicating an inversion of the physiological velocity gradient in chronic venous disease patients.
Chronic venous disease presents a subverted velocity gradient. These data introduce objective hemodynamics data, paving the way for further investigation in venous drainage direction determination.
在生理学中，深静脉腔的血流速度高于隐静脉腔，而隐静脉腔的血流速度又高于其属支。鉴于血流速度变化与压力梯度变化相关，本研究旨在评估慢性下肢静脉疾病患者静脉血流动力学的变化，从而为确定静脉回流方向提供更多线索。
对28例慢性静脉疾病患者（C2 - 6Ep、As、Pr）的40条下肢进行静脉超声扫描。在三个不同的静脉节段测量血流速度：功能不全属支起源上方2 cm处的大隐静脉（A组）、属支起源下方2 cm处的大隐静脉（B组）、距大隐静脉起源处2 cm的属支（C组）。
C组的舒张期平均血流速度（-21.3±8.5 cm/s）高于A组（-15.7±5.2 cm/s；p = 0.0001）和B组（-11.1±2.9 cm/s；p = 0.0001），这表明慢性静脉疾病患者的生理血流速度梯度发生了倒置。
慢性静脉疾病呈现出被颠覆的血流速度梯度。这些数据引入了客观的血流动力学数据，为进一步研究静脉回流方向奠定了基础。
